Two polynomials of the same degree $A(x)=a_nx^n+ \cdots + a_1x+a_0$ and $B(x)=b_nx^n+\cdots+b_1x+b_0$ are called friends is the coefficients $b_0,b_1, \ldots, b_n$ are a permutation of the coefficients $a_0,a_1, \ldots, a_n$. $P(x)$ and $Q(x)$ be two friendly polynomials with integer coefficients. If $P(16)=3^{2020}$, the smallest possible value of $|Q(3^{2020})|$.