For every sequence $p_1<p_2<\cdots<p_8$ of eight prime numbers, determine the largest integer $N$ for which the following equation has no solution in positive integers $x_1,\ldots,x_8$: $$p_1\, p_2\, \cdots\, p_8 \left( \frac{x_1}{p_1}+ \frac{x_2}{p_2}+ ~\cdots~ +\frac{x_8}{p_8} \right) ~~=~~ N $$ Proposed by Gerhard Woeginger, Austria