We use the following facts:
1:$a|b^4,b|c^4\Rightarrow a|b^4|c^{16}\Rightarrow ab|c^4c^{16}=c^{20}$
Similarly we get $b|a^{20}, c|a^{20}$
2:Since $c|b^4$ and $c|a^{16}$, the $c|a^x b^y$ for all $x,y$ positive integers with $x+y\geq 19$
Now analize the terms in the expansion of $(a+b+c)^{21}$.We'll show that all the terms are multiples of $abc$. For that notice we only need to worry about the terms that don't have $abc$, in other words, all terms that only have one or two beetween a,b,c. Lets only consider terms that have $a$ and $ab$,the rest being competely similar
1:$abc|a^{21}\iff bc|a^{20}$, which we know is true
2:$abc|a^x b^y\iff c|a^{x-1}b^{y-1}$, which we know is true because x-1+y-1=19
Then $abc$ divides all terms in $(a+b+c)^{21}$.